🌸Uterine cancer

#1Body weight[1]≈+353%

Across 30 prospective studies and 22,320 cases, each 5 BMI units went with 54% more endometrial cancer, the steepest anthropometric effect of any common cancer.

How would you describe your weight?

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#2Diabetes[2]+110%

Across 16 studies and 96,003 people, diabetes doubled endometrial cancer; type 1 diabetes carried an even larger, noisier figure (3 studies).

What’s your blood sugar like?

Same number, 2 answers: The meta-analysis compared diabetes with no diabetes; it did not split by how well it was controlled.

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#3Family history of the disease[3]+82%

Across 16 studies and over 37,000 cases, a first-degree relative (parent or sibling) with endometrial cancer went with 82% more endometrial cancer; a first-degree relative with colorectal cancer, which can share the same Lynch-syndrome genetics, added 17% more on its own.

Any strong family history of cancer?

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#4Waistline[1]≈+27%

The same meta-analysis found each 10 cm of waist circumference went with 27% more endometrial cancer, independent of BMI — central fat is the metabolically active kind.

How’s your waistline?

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#5Oral contraceptive use[4]Women; protective≈−42%

Pooling individual data from 36 studies and 27,276 women with endometrial cancer, every 5 years of oral contraceptive use was linked to 24% less endometrial cancer, after stratifying by age, parity, body weight, smoking and hormone therapy.

Have you ever used oral contraceptives (the pill)?

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#6Smoking[5]−37%

The one pill on this site where quitting is not the lever: in the Nurses’ Health Study (702 cases, 1.8 million person-years), current smokers had 37% less endometrial cancer than never smokers and former smokers 27% less, an anti-estrogenic effect that fades after quitting.

Do you smoke?

Same number, 2 answers: The cohort compared current smokers with never smokers and did not split by cigarettes a day.

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#7Few vegetables[6]−29%

Across 10 studies, the highest vegetable eaters had 29% less endometrial cancer than the lowest; fruit alone showed a smaller, non-significant effect, so this pill is really a vegetables pill wearing the quiz’s combined fruit-and-vegetables question.

How many servings of vegetables and fruit do you eat a day?

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#8Sugary drinks[7]+29%

In 92,777 UK Biobank women followed 13 years (682 cases), drinking more than one sugary drink a day went with 29% more endometrial cancer than none, and even under one a day went with 28% more; the effect ran mostly through estrogen-driven tumors, and body weight explained only about a fifth of it.

How often do you drink sugary drinks?

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#9No coffee or tea[8]−29%

Across 16 studies and 6,628 cases, the highest coffee drinkers had 29% less endometrial cancer than the lowest, with each extra daily cup worth about 8% less; the review found no reliable figure for sugary coffee drinks or energy drinks, only coffee and tea themselves.

What does your daily caffeine mostly look like?

Same number, 3 answers: The meta-analysis measured only coffee and tea, so sugary coffee drinks and energy drinks, sugar-free or not, all fall outside it and share one projected figure.

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#10Physical inactivity[9]−20%

Across 33 studies and 19,558 cases, the most active people had 20% less endometrial cancer than the least active.

How many days a week do you get 30+ minutes of exercise?

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#11Breastfeeding[10]Women; protective−11%

Pooling 17 studies of women who had given birth (8,981 with endometrial cancer), ever breastfeeding was linked to 11% less endometrial cancer, and the link was not explained by having more children.

Have you breastfed, and for how long in total?

Same number, 3 answers: The pooled study reports one figure for ever versus never breastfeeding among women who had given birth, so all three lengths share it; its per-child trend flattened after about 6 to 9 months.

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#12Sitting time[9]

Across 43 studies and over 4 million people, the most sedentary group had 32% more endometrial cancer than the least, independent of exercise; each extra 2 hours a day of sitting went with about 10% more.

How many hours a day are you sitting?

Same number, 2 answers: The review pooled each study’s most sedentary band against its least; it did not measure a separate band above eleven hours.

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